Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice
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چکیده
منابع مشابه
Heart Failure Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice
Background—Hydrogen sulfide (H 2 S) is an endogenous signaling molecule with potent cytoprotective effects. The present study evaluated the therapeutic potential of H 2 S in murine models of heart failure. Methods and Results—Heart failure was induced by subjecting mice either to permanent ligation of the left coronary artery for 4 weeks or to 60 minutes of left coronary artery occlusion follow...
متن کاملGenetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice.
BACKGROUND Hydrogen sulfide (H(2)S) is an endogenous signaling molecule with potent cytoprotective effects. The present study evaluated the therapeutic potential of H(2)S in murine models of heart failure. METHODS AND RESULTS Heart failure was induced by subjecting mice either to permanent ligation of the left coronary artery for 4 weeks or to 60 minutes of left coronary artery occlusion foll...
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Hydrogen sulfide (H2S), the third gas transmitter, has been proven to be neuroprotective in cerebral ischemic injury, but whether its effect is mediated by regulating autophagy is not yet clear. The present study was undertaken to explore the underlying mechanisms of exogenous H2S on autophagy regulation in cerebral ischemia. The effects and its connection with autophagy of NaHS, a H2S donor, w...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.920991